Title

Nonhistone chromosomal proteins and gene regulation

UMMS Affiliation

Department of Cell Biology

Date

3-1-1974

Document Type

Article

Medical Subject Headings

Animals; Chickens; Chromatin; *Chromosomes; DNA Replication; Electrophoresis, Polyacrylamide Gel; Female; *Genes, Regulator; Gonadal Steroid Hormones; Histones; Humans; Mice; Mitosis; Models, Biological; Nucleoproteins; Phosphoproteins; Progesterone; Protein Binding; Protein Biosynthesis; RNA; Rats; Receptors, Cell Surface; *Transcription, Genetic

Disciplines

Cell Biology

Abstract

Evidence from several model systems suggests that nonhistone chromosomal proteins may regulate gene expression in eukaryotic cells. The data indicate that the synthesis of new species of nonhistone chromosomal proteins as well as modifications of preexisting nonhistone chromosomal proteins are involved in the control of transcription. However, from the vast number of proteins included in this class, it is apparent that, in addition to regulating the transcription of defined genome loci, the nonhistone chromosomal proteins include enzymes that have a general function, proteins that are involved in determining the structure of chromatin, as well as proteins that serve as recognition sites for binding of regulatory macromolecules. The presence of a nucleoplasmic pool of nonhistone chromosomal proteins which may exchange with the chromatin has also been reported (89). While it is clear that the nonhistone chromosomal proteins play a key role in the regulation of gene expression, the exact manner in which they interact with the genome to initiate, modify, or augment the transcription of specific RNA molecules remains to be resolved.

Rights and Permissions

Citation: Science. 1974 Mar 1;183(127):817-24.

Related Resources

Link to Article in PubMed

PubMed ID

4359338