Title

Effects of selected sulfhydryl inhibitors on nonhistone chromosomal proteins of HeLa cells

UMMS Affiliation

Department of Cell Biology

Date

1-1-1975

Document Type

Article

Medical Subject Headings

DNA Nucleotidyltransferases; DNA, Neoplasm; Fibroblasts; Fluorides; Hela Cells; Heparin; Iodoacetates; Leucine; Malonates; Mechlorethamine; Neoplasm Proteins; Nucleoproteins; Tryptophan; Vitamin K

Disciplines

Cell Biology

Abstract

Effects of the SH inhibitor sodium iodoacetate, alone and with adjuncts menadiol diphosphate, sodium malonate, sodium fluoride and heparin, on incorporation of tryptophane-3 H into nonhistone chromosomal proteins of HeLa cells were examined. The drugs block incorporation of tryptophane-3 H into nonhistone chromosomal proteins far more than incorporation of leucine-3 H into total cellular proteins. Drug effects on thymidine phosphorylation and DNA synthesis in HeLa cells exceed corresponding effects on fibroblasts from normal healing wounds.

Rights and Permissions

Citation: Oncology. 1975;32(5-6):291-301.

Related Resources

Link to Article in PubMed

PubMed ID

1228540