Effects of selected sulfhydryl inhibitors on nonhistone chromosomal proteins of HeLa cells
Department of Cell Biology
Medical Subject Headings
DNA Nucleotidyltransferases; DNA, Neoplasm; Fibroblasts; Fluorides; Hela Cells; Heparin; Iodoacetates; Leucine; Malonates; Mechlorethamine; Neoplasm Proteins; Nucleoproteins; Tryptophan; Vitamin K
Effects of the SH inhibitor sodium iodoacetate, alone and with adjuncts menadiol diphosphate, sodium malonate, sodium fluoride and heparin, on incorporation of tryptophane-3 H into nonhistone chromosomal proteins of HeLa cells were examined. The drugs block incorporation of tryptophane-3 H into nonhistone chromosomal proteins far more than incorporation of leucine-3 H into total cellular proteins. Drug effects on thymidine phosphorylation and DNA synthesis in HeLa cells exceed corresponding effects on fibroblasts from normal healing wounds.
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Citation: Oncology. 1975;32(5-6):291-301.
Knock, F. E.; Stein, Gary S.; Davis, Jeudi; Galt, R. M.; Oester, Y. T.; and Sylvester, R., "Effects of selected sulfhydryl inhibitors on nonhistone chromosomal proteins of HeLa cells" (1975). Stein, Stein, Lian, vanWijnen Lab Publications. 215.