Title

The effect of SV40 transformation on the chromosomal proteins of 3T3 mouse embryo fibroblasts

UMMS Affiliation

Department of Cell Biology

Date

7-1-1976

Document Type

Article

Medical Subject Headings

Aged; Cell Line; *Cell Transformation, Neoplastic; DNA Replication; Electrophoresis, Polyacrylamide Gel; Histones; Humans; Infant, Newborn; Molecular Weight; Phosphates; Simian virus 40

Disciplines

Cell Biology

Abstract

The composition and metabolism of chromosomal proteins-histones and nonhistones chromosomal proteins-were examined in normal and SV40 transformed 3T3 mouse cells. Variations were observed, many of which were similar to those previously reported for normal and SV40 transformed W138 human diploid fibroblasts. The possible implications of these viral induced changes in the protein component of the genome for the phenotypic modifications which occur in transformed cells are discussed.

Rights and Permissions

Citation: Cell Differ. 1976 Jul;5(2):83-96.

Related Resources

Link to Article in PubMed

PubMed ID

183894