Histone proteins in HeLa S3 cells are synthesized in a cell cycle stage specific manner
Department of Cell Biology
Medical Subject Headings
*Cell Cycle; Cell Nucleus; Cytarabine; Cytoplasm; Female; Hela Cells; Histones; Humans; Protein Biosynthesis; Transcription, Genetic
The synthesis of histone proteins in G1 and S phase HeLa S3 cells was examined by two-dimensional electrophoretic fractionation of nuclear and total cellular proteins. Newly synthesized histones were detected only in S phase cells. Histone messenger RNA sequences, as detected by hybridization with cloned human histone genes, were present in the cytoplasm of S phase but not G1 cells.
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Citation: Science. 1982 Feb 5;215(4533):683-5.
Marashi, Farhad; Baumbach, Lisa L.; Rickles, R.; Sierra, F.; Stein, Janet L.; and Stein, Gary S., "Histone proteins in HeLa S3 cells are synthesized in a cell cycle stage specific manner" (1982). Stein, Stein, Lian, vanWijnen Lab Publications. 161.