Title

Histone proteins in HeLa S3 cells are synthesized in a cell cycle stage specific manner

UMMS Affiliation

Department of Cell Biology

Date

2-5-1982

Document Type

Article

Medical Subject Headings

*Cell Cycle; Cell Nucleus; Cytarabine; Cytoplasm; Female; Hela Cells; Histones; Humans; Protein Biosynthesis; Transcription, Genetic

Disciplines

Cell Biology

Abstract

The synthesis of histone proteins in G1 and S phase HeLa S3 cells was examined by two-dimensional electrophoretic fractionation of nuclear and total cellular proteins. Newly synthesized histones were detected only in S phase cells. Histone messenger RNA sequences, as detected by hybridization with cloned human histone genes, were present in the cytoplasm of S phase but not G1 cells.

Rights and Permissions

Citation: Science. 1982 Feb 5;215(4533):683-5.

Related Resources

Link to Article in PubMed

PubMed ID

7058333