Title

Selective expression of histone genes in mouse-human hybrid cells

UMMS Affiliation

Department of Cell Biology

Date

8-1-1985

Document Type

Article

Medical Subject Headings

Animals; *Gene Expression Regulation; Histones; Humans; Hybrid Cells; Mice; Protein Processing, Post-Translational; RNA, Messenger

Disciplines

Cell Biology

Abstract

Mouse-human hybrid cells preferentially segregating mouse chromosomes contain predominantly human histone mRNAs and synthesize human histone proteins. In contrast, hybrids segregating human chromosomes contain both human and murine histone mRNAs, yet synthesize only mouse histone proteins. These results suggest transcriptional control of histone gene expression in hybrids segregating mouse chromosomes and post-transcriptional regulation in hybrids segregating human chromosomes.

Rights and Permissions

Citation: Exp Cell Res. 1985 Aug;159(2):280-6.

Related Resources

Link to Article in PubMed

PubMed ID

4029271