Selective expression of histone genes in mouse-human hybrid cells
Department of Cell Biology
Medical Subject Headings
Animals; *Gene Expression Regulation; Histones; Humans; Hybrid Cells; Mice; Protein Processing, Post-Translational; RNA, Messenger
Mouse-human hybrid cells preferentially segregating mouse chromosomes contain predominantly human histone mRNAs and synthesize human histone proteins. In contrast, hybrids segregating human chromosomes contain both human and murine histone mRNAs, yet synthesize only mouse histone proteins. These results suggest transcriptional control of histone gene expression in hybrids segregating mouse chromosomes and post-transcriptional regulation in hybrids segregating human chromosomes.
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Citation: Exp Cell Res. 1985 Aug;159(2):280-6.
Marashi, Farhad; Croce, Carlo M.; Stein, Janet L.; and Stein, Gary S., "Selective expression of histone genes in mouse-human hybrid cells" (1985). Stein, Stein, Lian, vanWijnen Lab Publications. 141.