eScholarship@UMMS

Title

Liquid ventilation with perflubron in the treatment of rats with pneumococcal pneumonia

Authors

Eric W. Dickson, University of Massachusetts Medical School
Stephen O. Heard, University of Massachusetts Medical SchoolFollow
Thomas E. Tarara
Jeffry G. Weers
Angela B. Brueggemann
Gary V. Doern

UMMS Affiliation

Department of Physiology; Department of Emergency Medicine; Department of Anesthesiology; Department of Surgery

Date

3-13-2002

Document Type

Article

Medical Subject Headings

Animals; Anti-Bacterial Agents; Combined Modality Therapy; Fluorocarbons; Infusions, Parenteral; *Liquid Ventilation; Male; Pneumonia, Pneumococcal; Random Allocation; Rats; Rats, Wistar; Statistics, Nonparametric; Survival Analysis

Disciplines

Anesthesiology | Life Sciences | Medicine and Health Sciences | Respiratory Tract Diseases

Abstract

OBJECTIVE: To determine the efficacy of liquid ventilation using a medical-grade perfluorocarbon (perflubron) combined with parenteral or intratracheal antibiotics in a rat model of pneumonia.

DESIGN: Prospective, laboratory investigation.

SETTING: Experimental laboratory in a university medical center.

SUBJECTS: Wistar rats (n = 112).

INTERVENTIONS: One day after intratracheal inoculation with Streptococcus pneumoniae, rats received one of five experimental treatments or no treatment (control): modified liquid ventilation (MLV), intramuscular ampicillin, MLV plus intramuscular ampicillin, MLV with intratracheal ampicillin, or MLV plus ampicillin PulmoSpheres.

MEASUREMENTS AND MAIN RESULTS: Animals receiving MLV plus intramuscular ampicillin, MLV with intratracheal ampicillin, or MLV plus ampicillin PulmoSpheres had significantly improved 10-day survival rates (85%, 72%, and 72%, respectively) compared with all other groups (0% to 25%).

CONCLUSIONS: MLV in combination with either intramuscular, intratracheal, or PulmoSpheres ampicillin improved survival as compared with MLV alone or the same dose of antibiotics delivered intramuscularly.

Rights and Permissions

Citation: Crit Care Med. 2002 Feb;30(2):393-5.

Related Resources

Link to Article in PubMed

Comments

Medical student Eric Dickson participated in this study as part of the Senior Scholars research program.

Repository Citation

Dickson, Eric W.; Heard, Stephen O.; Tarara, Thomas E.; Weers, Jeffry G.; Brueggemann, Angela B.; and Doern, Gary V., "Liquid ventilation with perflubron in the treatment of rats with pneumococcal pneumonia" (2002). University of Massachusetts Medical School. Senior Scholars Program. Paper 78.
http://escholarship.umassmed.edu/ssp/78