Senior Scholars Program

Title

Liquid ventilation with perflubron in the treatment of rats with pneumococcal pneumonia

UMMS Affiliation

Department of Physiology; Department of Emergency Medicine; Department of Anesthesiology; Department of Surgery

Date

3-13-2002

Document Type

Article

Medical Subject Headings

Animals; Anti-Bacterial Agents; Combined Modality Therapy; Fluorocarbons; Infusions, Parenteral; *Liquid Ventilation; Male; Pneumonia, Pneumococcal; Random Allocation; Rats; Rats, Wistar; Statistics, Nonparametric; Survival Analysis

Disciplines

Anesthesiology | Life Sciences | Medicine and Health Sciences | Respiratory Tract Diseases

Abstract

OBJECTIVE: To determine the efficacy of liquid ventilation using a medical-grade perfluorocarbon (perflubron) combined with parenteral or intratracheal antibiotics in a rat model of pneumonia.

DESIGN: Prospective, laboratory investigation.

SETTING: Experimental laboratory in a university medical center.

SUBJECTS: Wistar rats (n = 112).

INTERVENTIONS: One day after intratracheal inoculation with Streptococcus pneumoniae, rats received one of five experimental treatments or no treatment (control): modified liquid ventilation (MLV), intramuscular ampicillin, MLV plus intramuscular ampicillin, MLV with intratracheal ampicillin, or MLV plus ampicillin PulmoSpheres.

MEASUREMENTS AND MAIN RESULTS: Animals receiving MLV plus intramuscular ampicillin, MLV with intratracheal ampicillin, or MLV plus ampicillin PulmoSpheres had significantly improved 10-day survival rates (85%, 72%, and 72%, respectively) compared with all other groups (0% to 25%).

CONCLUSIONS: MLV in combination with either intramuscular, intratracheal, or PulmoSpheres ampicillin improved survival as compared with MLV alone or the same dose of antibiotics delivered intramuscularly.

Rights and Permissions

Citation: Crit Care Med. 2002 Feb;30(2):393-5.

Related Resources

Link to Article in PubMed

Comments

Medical student Eric Dickson participated in this study as part of the Senior Scholars research program.

PubMed ID

11889317