Senior Scholars Program


Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention

UMMS Affiliation

Department of Radiation Oncology; Department of Cancer Biology; Program in Molecular Medicine; Department of Cell Biology; Department of Surgery; School of Medicine

Faculty Advisor

Thomas Fitzgerald



Document Type


Medical Subject Headings

Adenocarcinoma; Humans; Male; Neoplasm Staging; Prostate-Specific Antigen; Prostatic Neoplasms; Radiation Tolerance; Risk Factors; Treatment Outcome


Male Urogenital Diseases | Neoplasms | Oncology | Radiology | Urology


Adenocarcinoma of the prostate remains a significant public health problem and a prevalent cancer in men. Prostate-specific antigen used as a biomarker has established a clear migration of patients towards earlier-stage disease at presentation. However, in spite of process improvements in traditional therapies including surgery, radiation therapy, and hormone management, there remains a significant cohort of patients with intermediate- to high-risk features for poor outcome in spite of optimal use of traditional management. This paper focuses on future treatment strategies integrating new therapeutic options with traditional management, specifically to pinpoint new radiation therapy strategies.

Rights and Permissions

Citation: Expert Rev Anticancer Ther. 2008 Jun;8(6):967-74. doi: 10.1586/14737140.8.6.967. Link to article on publisher's site

Related Resources

Link to Article in PubMed


Medical student Jiayi Huang participated in this study as part of the Senior Scholars research program at the University of Massachusetts Medical School.

PubMed ID