Senior Scholars Program

Title

Reclassification of a tubal leiomyosarcoma as an eGIST by molecular evaluation of c-KIT

UMMS Affiliation

School of Medicine

Faculty Advisor

Michael V. Seiden

Date

5-2006

Document Type

Article

Medical Subject Headings

Base Sequence; Diagnosis, Differential; Fallopian Tube Neoplasms; Female; Gastrointestinal Stromal Tumors; Humans; Leiomyosarcoma; Middle Aged; Molecular Sequence Data; Proto-Oncogene Proteins c-kit

Disciplines

Female Urogenital Diseases and Pregnancy Complications | Neoplasms | Obstetrics and Gynecology | Oncology

Abstract

BACKGROUND: Extragastrointestinal stromal tumors (eGISTs) are rare mesenchymal-derived tumors arising outside of the GI tract. eGISTs are often histologically confused with leiomyosarcoma. Distinction between eGIST and leiomyosarcoma is critical because of the unique responsiveness of eGISTs to the molecularly targeted agent imatinib.

CASE: A woman presented with a history of tubal spindle cell tumor that was initially diagnosed and treated as a leiomyosarcoma. Because of minimal response to sarcoma directed chemotherapy, the possibility that the tumor was in fact an eGIST was investigated and supported by immunohistochemical and mutational analyses of the c-Kit receptor tyrosine kinase. The patient currently has stable disease control on imatinib for the last 18 months.

CONCLUSIONS: The possibility of eGIST should be considered in the differential diagnosis of tumors with a spindle cell morphology in the gynecologic tract especially when involving the ovary, fallopian tube, or uterine serosa.

Rights and Permissions

Citation: Gynecol Oncol. 2006 May;101(2):363-6. Epub 2006 Jan 24. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Comments

Medical student Steven Solano initially participated in this study as part of the Senior Scholars research program at the University of Massachusetts Medical School.

PubMed ID

16439005