Two-way traffic: centrosomes and the cell cycle
Department of Cell Biology
Medical Subject Headings
Animals; Cell Cycle; Centrosome; Microsurgery; Signal Transduction
The well recognized activities of the mammalian centrosome--microtubule nucleation, duplication, and organization of the primary cilium--are under the control of the cell cycle. However, the centrosome is more than just a follower of the cell cycle; it can also be essential for the cell to transit G1 and enter S phase. How the centrosome influences G1 progression is a mystery.
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Citation: Nat Rev Mol Cell Biol. 2005 Sep;6(9):743-8. Link to article on publisher's site