Centriole biogenesis: a tale of two pathways
Department of Cell Biology
Medical Subject Headings
Animals; Cell Cycle; Cell Cycle Proteins; Cells, Cultured; Centrioles; Drosophila; Embryo, Nonmammalian; Female; Humans; Models, Biological; Ovum
Two recent studies in Drosophila demonstrate that overexpression of proteins required for centriole duplication can not only induce centriole over-duplication in cells containing centrioles, but can also drive de novo centriole assembly in unfertilized eggs that initially lack centrioles. These studies offer a new perspective on the mechanisms that control centriole duplication.
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Citation: Nat Cell Biol. 2007 Jul;9(7):736-8. Link to article on publisher's site