Title

Impact of inflammation on the osteoblast in rheumatic diseases

UMMS Affiliation

Department of Medicine, Division of Rheumatology

Date

3-2014

Document Type

Article

Medical Subject Headings

Arthritis, Rheumatoid; Bone Remodeling; Bone Resorption; Cell Differentiation; Cytokines; Humans; Inflammation; Inflammation Mediators; Osteoblasts; Osteoclasts; Spondylitis, Ankylosing

Disciplines

Cells | Musculoskeletal Diseases | Rheumatology | Skin and Connective Tissue Diseases

Abstract

Normal bone remodeling depends upon a balance between the action of bone-resorbing cells, osteoclasts, and bone-forming cells, osteoblasts. When this balance is disrupted, as is seen in inflammatory diseases such as rheumatoid arthritis (RA) and ankylosing spondylitis (AS), abnormal bone loss or bone formation occurs. In RA, proinflammatory cytokines induce osteoclast differentiation and inhibit osteoblast maturation, leading to articular bone erosions. In contrast, the inflammatory milieu in AS leads to excessive osteoblast activation and bone formation at sites of entheses. While much information exists about the effects of proinflammatory cytokines on osteoclast differentiation and function, more recent studies have begun to elucidate the impact of inflammation on the osteoblast. This review will summarize the mechanisms by which inflammation perturbs bone homeostasis, with a specific focus on the osteoblast.

Rights and Permissions

Citation: Curr Osteoporos Rep. 2014 Mar;12(1):9-16. doi: 10.1007/s11914-013-0183-y. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

24363057