Lymphocyte subsets and Langerhans' cells in toxic epidermal necrolysis. Report of a case

UMMS Affiliation

Department of Medicine, Division of Rheumatology



Document Type


Medical Subject Headings

Animals; Antibodies, Monoclonal; Biopsy; Epidermis; Graft vs Host Disease; Humans; Immunoenzyme Techniques; *Langerhans Cells; Male; Middle Aged; Prochlorperazine; Stevens-Johnson Syndrome; *T-Lymphocytes; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory


Immune System Diseases | Medical Pathology | Skin and Connective Tissue Diseases | Stomatognathic Diseases


Toxic epidermal necrolysis is a life-threatening disease, the pathogenesis of which remains largely unknown. Histologically, in addition to the characteristic epidermal alterations, there is a sparse mononuclear cell infiltrate in the dermis. The immunologic characteristics of this infiltrate are not well known. In a case of drug-induced toxic epidermal necrolysis with fatal outcome in a 48-year-old man, we demonstrated that the majority of the inflammatory cells were of helper/inducer T-lymphocyte subsets, having only a minority of cytotoxic/suppressor T-lymphocytes and rare cells with natural killer cell phenotype. The significance of these observations is discussed, with reference to the occurrence of lesions at epithelial sites bearing local networks of antigen-presenting cells (Langerhans' cells).

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Citation: Arch Dermatol. 1986 Apr;122(4):455-8. doi:10.1001/archderm.1986.01660160111029.


At the time of publication, Ellen Gravallese was not yet affiliated with the University of Massachusetts Medical School

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