UMMS Affiliation

Department of Medicine, Division of Rheumatology

Date

7-17-2003

Document Type

Response or Comment

Medical Subject Headings

Animals; Arthritis, Rheumatoid; Disease Models, Animal; Epitopes; Inflammation; Mice; Mice, Inbred C57BL; Osteopontin; RNA, Messenger; Sialoglycoproteins

Disciplines

Cells | Medical Immunology | Musculoskeletal Diseases | Rheumatology | Skin and Connective Tissue Diseases

Abstract

The molecular mechanisms underlying the putative role of osteopontin in the chronic inflammatory disease rheumatoid arthritis are unclear. A study in a murine model of arthritis now demonstrates that a specific antibody directed against the exposed osteopontin epitope SLAYGLR is capable of preventing inflammatory cell infiltration in arthritic joints.

Rights and Permissions

Citation: J Clin Invest. 2003 Jul;112(2):147-9. Link to article on publisher's site

Comments

At the time of publication, Ellen Gravallese was not yet affiliated with the University of Massachusetts Medical School.

Publisher PDF posted as allowed by the publisher's author rights policy at http://static.the-jci.org/content_assets/admin/forms/jcicopyright.pdf.

Related Resources

Link to Article in PubMed

Keywords

osteopontin, rheumatoid arthritis

PubMed ID

12865402

 
 

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