Hand bone mineral density is associated with both total hip and lumbar spine bone mineral density in post-menopausal women with RA
Authors
Desai, Sonali P.Gravallese, Ellen M.
Shadick, Nancy A.
Glass, Roberta
Cui, Jing
Frits, Michelle
Chibnik, Lori B.
Maher, Nancy
Weinblatt, Michael E.
Solomon, Daniel H.
UMass Chan Affiliations
Department of Medicine, Division of RheumatologyDocument Type
Journal ArticlePublication Date
2010-03-01Keywords
Absorptiometry, PhotonAge Factors
Aged
Arthritis, Rheumatoid
Bone Density
Cross-Sectional Studies
Epidemiologic Methods
Female
Hip Joint
Humans
Lumbar Vertebrae
Metacarpal Bones
Middle Aged
Postmenopause
Time Factors
Musculoskeletal Diseases
Rheumatology
Skin and Connective Tissue Diseases
Women's Health
Metadata
Show full item recordAbstract
OBJECTIVE: RA is associated with localized bone loss in the hands, as well as generalized osteoporosis. We evaluated the relationship between hand digital X-ray radiogrammetry BMD (DXR-BMD) and total hip and lumbar spine BMD. METHODS: We conducted a cross-sectional study of 138 post-menopausal women with RA. The DXR-BMD was calculated based on digitized hand radiographs. Measurements of the total hip and lumbar spine BMD were performed by a DXA-BMD (BMDa) scan. Patient and physician questionnaires and laboratory samples supplied information on relevant covariates. Separate multivariate linear regression models were constructed to determine the cross-sectional relationship between hand DXR-BMD (independent variable) and total hip or lumbar spine BMD (dependent variables). RESULTS: The cohort comprised women with a median age of 61 years and RA disease duration of 13 years. Seventy-six per cent were either RF and/or anti-cyclic citrullinated peptide (anti-CCP) positive and most had moderate disease activity [median disease activity score-28 joint count (DAS28) 3.7]. Hand DXR-BMD was significantly associated with total hip BMD (beta = 0.61; P < 0.0001) and lumbar spine BMD (beta = 0.62; P < 0.0008) in adjusted models. CONCLUSIONS: This study suggests that hand DXR-BMD is associated with both the total hip and lumbar spine BMD among post-menopausal women with RA. The relationship between bone loss in the hands and generalized osteoporosis should be further explored in longitudinal studies of patients with RA.Source
Rheumatology (Oxford). 2010 Mar;49(3):513-9. doi: 10.1093/rheumatology/kep385. Epub 2009 Dec 21. Link to article on publisher's siteDOI
10.1093/rheumatology/kep385Permanent Link to this Item
http://hdl.handle.net/20.500.14038/48748PubMed ID
20026562Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1093/rheumatology/kep385