Synovial tissue response to treatment with Campath-1H
Department of Medicine, Division of Rheumatology
Medical Subject Headings
Antigens, CD; Antigens, CD19; Antigens, CD20; Antigens, CD3; Antigens, Differentiation, B-Lymphocyte; *Antigens, Neoplasm; Arthritis, Rheumatoid; B-Lymphocyte Subsets; CD4-Positive T-Lymphocytes; *Glycoproteins; Humans; Immunohistochemistry; Knee Prosthesis; Lymphopenia; Paraffin Embedding; Synovial Membrane
Musculoskeletal Diseases | Rheumatology | Skin and Connective Tissue Diseases
OBJECTIVE: Therapeutic trials in rheumatoid arthritis with the monoclonal antibody Campath-1H have demonstrated recurrent clinical synovitis in some patients, despite profound depletion of circulating lymphocytes. This study was undertaken to examine the cellular infiltrates in synovial tissue at a time of persistent peripheral lymphopenia.
METHODS: Immunohistochemical staining of synovial tissue and peripheral blood lymphocyte phenotyping.
RESULTS: Synovial tissues from 2 patients with recurrent synovitis after Campath-1H therapy contained significant T lymphocytic infiltrates at a time when circulating T lymphocytes were markedly depleted.
CONCLUSION: These results demonstrate that peripheral blood analysis may not accurately reflect the synovial tissue response to monoclonal antibody therapy.
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Citation: Arthritis Rheum. 1995 Feb;38(2):254-8. DOI: 10.1002/art.1780380215
Ruderman, Eric M.; Weinblatt, Michael E.; Thurmond, Linda M.; Pinkus, Geraldine S.; and Gravallese, Ellen M., "Synovial tissue response to treatment with Campath-1H" (1995). Rheumatology Publications and Presentations. 17.