Title

Regression of lymphoproliferative disorder after treatment for hepatitis C virus infection in a patient with partial trisomy 3, Bcl-2 overexpression, and type II cryoglobulinemia

UMMS Affiliation

Department of Medicine, Division of Rheumatology

Date

3-15-2002

Document Type

Article

Medical Subject Headings

Chromosomes, Human, Pair 3; Cryoglobulinemia; Hepatitis C; Humans; Lymphoproliferative Disorders; Male; Middle Aged; Proto-Oncogene Proteins c-bcl-2; Treatment Outcome; Trisomy; Vasculitis

Disciplines

Hemic and Lymphatic Diseases

Abstract

A patient with type II cryoglobulinemic vasculitis and hepatitis C virus (HCV) infection presented with a leukemiclike proliferation of B cells bearing marginal zone B-cell phenotypic markers. A partial trisomy 3 (bands 3q11-29) and overexpression of Bcl-2 without t(14;18) translocation was detected in the monoclonal B cells that were classic rheumatoid factor-producing B cells bearing the WA cross-idiotype. Treatment with interferon-alpha produced a complete clinical remission and synchronous marked decreases in viremia and monoclonal B-cell prevalence. This is the first report of partial trisomy 3 and Bcl-2 overexpression in type II cryoglobulinemic vasculitis associated with HCV infection. Further studies of HCV-infected patients with and without type II cryoglobulinemia are required to determine the prevalence and possible physiologic and/or pathophysiologic significance of these findings.

Rights and Permissions

Citation: Blood. 2002 Mar 15;99(6):2259-61. Link to article on publisher's site

Comments

At the time of publication, Jonathan Kay was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID

11877309