Title

Nephrogenic systemic fibrosis: a systemic fibrosing disease resulting from gadolinium exposure

UMMS Affiliation

Department of Medicine, Division of Rheumatology

Date

8-2012

Document Type

Article

Medical Subject Headings

Contracture; Contrast Media; Diagnosis, Differential; Gadolinium; Humans; Hyperpigmentation; Nephrogenic Fibrosing Dermopathy; induced; Renal Insufficiency, Chronic; Risk Factors; Skin

Disciplines

Musculoskeletal Diseases | Rheumatology | Skin and Connective Tissue Diseases

Abstract

Nephrogenic systemic fibrosis (NSF) is an iatrogenic fibrosing disorder that primarily affects individuals with chronic kidney disease (CKD) following exposure to gadolinium-based contrast agents (GBCAs) during imaging procedures. NSF is characterised by skin thickening, tethering and hyperpigmentation; flexion contractures of joints; and extracutaneous fibrosis. This article reviews the history, clinical manifestations, epidemiology, histopathology and pathophysiology of this disabling disease.

Rights and Permissions

Citation: Best Pract Res Clin Rheumatol. 2012 Aug;26(4):489-503. doi: 10.1016/j.berh.2012.07.008. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

23040363