Title

Nephrogenic systemic fibrosis: a gadolinium-associated fibrosing disorder in patients with renal dysfunction

UMMS Affiliation

Department of Medicine, Division of Rheumatology

Date

12-1-2008

Document Type

Article

Medical Subject Headings

Contrast Media; Drug Eruptions; Gadolinium; Humans; Hyperpigmentation; Nephrogenic Fibrosing Dermopathy; Renal Insufficiency, Chronic

Disciplines

Musculoskeletal Diseases | Rheumatology | Skin and Connective Tissue Diseases

Abstract

Nephrogenic systemic fibrosis (NSF) is a debilitating fibrosing disorder that develops in patients with underlying kidney disease following exposure to gadolinium-containing contrast agents. NSF presents with cutaneous hyperpigmentation and induration and joint contractures, but fibrosis may also develop in other organs. NSF has been observed in up to 18% of patients receiving chronic haemodialysis and also may occur in individuals with stages 3 and 4 chronic kidney disease and, occasionally, in individuals who had experienced acute renal failure. Mortality is increased significantly among individuals with NSF. Although no medical treatment has been proved to be universally effective in patients with NSF, imatinib mesylate shows potential as a therapeutic agent and is currently being studied in these patients.

Rights and Permissions

Citation: Ann Rheum Dis. 2008 Dec;67 Suppl 3:iii66-9. doi: 10.1136/ard.2008.102475. Link to article on publisher's site

Comments

At the time of publication, Jonathan Kay was not yet affiliated with the University of Massachusetts Medical School.

Related Resources

Link to Article in PubMed

PubMed ID

19022818