Molecular magnetic resonance contrast agents for the detection of cancer: past and present
Department of Radiology
Medical Subject Headings
Contrast Media; Humans; Magnetic Resonance Imaging; Molecular Imaging; Molecular Probes; Neoplasms
Diagnosis | Equipment and Supplies | Investigative Techniques | Neoplasms | Radiology
Magnetic resonance imaging (MRI) is a powerful diagnostic tool with unsurpassed spatial resolution that is capable of providing detailed information about the structure and composition of tumors. The use of exogenously administered contrast agents allows compartment-specific enhancement of tumors, enabling imaging of functional blood and interstitial volumes. Current efforts are directed at enhancing the capabilities of MRI in oncology by adding contrast agents with molecular specificities to the growing armamentarium of diagnostic probes that produce signal by changing local proton relaxation times as a consequence of specific contrast agent binding to cell surface receptors or extracellular matrix components. We review herein the most notable examples, illustrating major trends in the development of specific probes for high-resolution imaging in molecular oncology.
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Citation: Semin Oncol. 2011 Feb;38(1):42-54. doi: 10.1053/j.seminoncol.2010.11.002. Link to article on publisher's site
Bogdanov, Alexei A. Jr. and Mazzanti, Mary L., "Molecular magnetic resonance contrast agents for the detection of cancer: past and present" (2011). Radiology Publications and Presentations. 99.