Title

Molecular magnetic resonance contrast agents for the detection of cancer: past and present

UMMS Affiliation

Department of Radiology

Date

2-2011

Document Type

Article

Medical Subject Headings

Contrast Media; Humans; Magnetic Resonance Imaging; Molecular Imaging; Molecular Probes; Neoplasms

Disciplines

Diagnosis | Equipment and Supplies | Investigative Techniques | Neoplasms | Radiology

Abstract

Magnetic resonance imaging (MRI) is a powerful diagnostic tool with unsurpassed spatial resolution that is capable of providing detailed information about the structure and composition of tumors. The use of exogenously administered contrast agents allows compartment-specific enhancement of tumors, enabling imaging of functional blood and interstitial volumes. Current efforts are directed at enhancing the capabilities of MRI in oncology by adding contrast agents with molecular specificities to the growing armamentarium of diagnostic probes that produce signal by changing local proton relaxation times as a consequence of specific contrast agent binding to cell surface receptors or extracellular matrix components. We review herein the most notable examples, illustrating major trends in the development of specific probes for high-resolution imaging in molecular oncology.

Rights and Permissions

Citation: Semin Oncol. 2011 Feb;38(1):42-54. doi: 10.1053/j.seminoncol.2010.11.002. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID

21362515