Experimental demonstration of benchtop x-ray fluorescence computed tomography (XFCT) of gold nanoparticle-loaded objects using lead- and tin-filtered polychromatic cone-beams
Department of Radiology
Medical Subject Headings
Color; Cone-Beam Computed Tomography; Gold; Lead; Metal Nanoparticles; Phantoms, Imaging; Tin
Biological and Chemical Physics | Investigative Techniques | Medical Biophysics | Nanotechnology | Radiology
This report presents the first experimental demonstration, to our knowledge, of benchtop polychromatic cone-beam x-ray fluorescence computed tomography (XFCT) for a simultaneous determination of the spatial distribution and amount of gold nanoparticles (GNPs) within small-animal-sized objects. The current benchtop experimental setup successfully produced XFCT images accurately showing the regions containing small amount of GNPs (on the order of 0.1 mg) within a 3 cm diameter plastic phantom. In particular, the performance of the current XFCT setup was improved remarkably (e.g., at least a factor of 3 reduction in XFCT scan time) using a tin-filtered polychromatic beam in comparison with a lead-filtered beam. The results of this study strongly suggest that the current benchtop XFCT configuration can be made practical with a few modifications such as the deployment of array detectors, while meeting realistic constraints on x-ray dose, scan time and image resolution for routine pre-clinical in vivo imaging with GNPs.
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Citation: Phys Med Biol. 2012 Dec 7;57(23):N457-67. doi: 10.1088/0031-9155/57/23/N457. Epub 2012 Nov 8. Link to article on publisher's site
Jones, Bernard L.; Manohar, Nivedh; Reynoso, Francisco; Karellas, Andrew; and Cho, Sang Hyun, "Experimental demonstration of benchtop x-ray fluorescence computed tomography (XFCT) of gold nanoparticle-loaded objects using lead- and tin-filtered polychromatic cone-beams" (2012). Radiology Publications and Presentations. 70.