Flow diverter implantation in a rat model of sidewall aneurysm: a feasibility study
Department of Radiology, Division of Neuroimaging and Intervention; New England Center for Stroke Research
Neurology | Radiology | Surgery
BACKGROUND: More challenging animal models are needed to elucidate the efficacy of flow diverter (FD) designs and the mechanisms behind observed complications. The purpose of this study is to demonstrate the feasibility of implanting a FD in a sidewall aneurysm rat model.
METHODS: An end-to-side anastomosis was created in the abdominal aorta of 36 rats using a decellularized donor pouch. A FD was subsequently implanted.
RESULTS: After up to 3 months of follow-up, we observed that rats displayed normal growth and behavior. Mortality within the groups was low (2 rats, 5.6%). All aneurysms thrombosed after FD implantation and showed progressive soft tissue replacement of the thrombus during follow-up. The abdominal aortas remained patent.
CONCLUSIONS: This model can be used to test the effects of FDs in future studies.
Aneurysm, Artery, Flow Diverter, Technique
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Citation: J Neurointerv Surg. 2017 Feb 8. pii: neurintsurg-2016-012878. 10.1136/neurintsurg-2016-012878. Link to article on publisher's site
Journal of neurointerventional surgery
Aquarius, Rene; Smits, Debby; Gounis, Matthew J.; Leenders, William P.; and de Vries, Joost, "Flow diverter implantation in a rat model of sidewall aneurysm: a feasibility study" (2017). Radiology Publications and Presentations. 339.