Title

Finding the striatum in sheep: use of a multi-modal guided approach for convection enhanced delivery

UMMS Affiliation

Department of Radiology; Department of Neurosurgery; Department of Microbiology and Physiological Systems; Department of Medicine; Department of Animal Medicine; Department of Neurology; Department of Pediatrics, Division of Pediatric Pulmonology; Gene Therapy Center

Date

1-1-2013

Document Type

Article

Disciplines

Animal Sciences | Nervous System Diseases | Radiology | Therapeutics

Abstract

Our goal is delivery of a long-term treatment for Huntington's disease. We administer intracerebrally in sheep adeno-associated virus (AAV) to establish optimal safety, spread and neuronal uptake of AAV based therapeutics. Sheep have large gyrencephalic brains and offer the opportunity to study a transgenic Huntington's disease model. However, lack of a relevant brain stereotactic atlas and the difficulty of skull fixation make conventional stereotaxy unreliable. We describe a multi-modal image-guidance technique to achieve accurate placement of therapeutics into the sheep striatum.

Rights and Permissions

Citation: J Huntingtons Dis. 2013;2(1):41-5. doi: 10.3233/JHD-130053. Link to article on publisher's site

Related Resources

Link to Article in PubMed

Keywords

Sheep brain, huntingtin therapeutics, stereotaxis placement

PubMed ID

25063428