Postsurgical treatment of early-stage breast cancer with electronic brachytherapy: outcomes and health-related quality of life at 1 year
Department of Radiation Oncology
Medical Subject Headings
Adult; Aged; Aged, 80 and over; *Brachytherapy; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Female; Follow-Up Studies; Humans; Middle Aged; Neoplasm Grading; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Prognosis; *Quality of Life; Registries; Survival Rate
Neoplasms | Oncology
OBJECTIVES: This multicenter registry followed up patients with early-stage breast cancer treated with breast-conserving surgery and electronic brachytherapy (EBT). This report provides 1- and 2-year updates to the initial publication.
METHODS: Patients were of age 50 years or more with invasive carcinoma or ductal carcinoma in situ, tumor size
RESULTS: Of the 69 patients enrolled, 62 were evaluated at 1 year and 20 patients at 2 years after treatment. At 1 year, 28 (45.2%) patients reported adverse events that were possibly, probably, or definitely related to treatment. Most (90%) were grade 1: manageable and typical of radiation therapy. Four events were grade 2: induration/firmness (2), field contracture (1), and seroma (1). One event was grade 3: a draining fistula at the lumpectomy site due to residual effects of a breast infection at 1 month. No recurrences have been reported. Cosmetic ratings were excellent or good in 93.4% of patients at 1 year. Most patients (69%) were energetic most or all of the time. Most patients (69% to 98%) were not affected by individual symptoms of breast disease at 1 year. Generally patients who had an adverse event did not report the corresponding symptom on the quality-of-life questionnaire.
CONCLUSIONS: This registry followed up patients with early-stage breast cancer at 1 and 2 years after breast-conserving surgery and EBT. No recurrences have been reported, and adverse effects were acceptable.
Rights and Permissions
Citation: Am J Clin Oncol. 2013 Oct;36(5):430-5. doi: 10.1097/COC.0b013e31825493bb. Link to article on publisher's site
Patel, Rakesh R.; Beitsch, Peter D.; Nichols, Timothy D.; Lorenzetti, John D.; Wurzer, James C.; Tucker, James C.; Nunn, George W.; Laduzinsky, Susan J.; Kugler, Morris A.; Simmons, Dwelvin L.; Gilligan, Michael S.; Roy, Tapan; Foley, Jonathon K.; Thropay, John P.; Odou, Mark William; Bornstein, Bruce A.; Tito, Elizabeth P.; Chadha, Manjeet; Boolbol, Susan K.; Lane, Steven C.; and White, Julie G., "Postsurgical treatment of early-stage breast cancer with electronic brachytherapy: outcomes and health-related quality of life at 1 year" (2013). Radiation Oncology Publications and Presentations. Paper 30.