Prompt Repeat Testing After Out-of-Range INR Values: A Quality Indicator for Anticoagulation Care
Department of Quantitative Health Sciences
Anticoagulants; Blood Coagulation; Quality Indicators, Health Care; International Normalized Ratio; Blood Coagulation Tests
Biostatistics | Epidemiology | Health Services Research
Background- Improved control of oral anticoagulation reduces adverse events. A program of quality measurement is needed for oral anticoagulation. The interval until the next test after an out-of-range International Normalized Ratio (INR) value (the "follow-up interval") could serve as a process of care measure.
Methods and Results- We studied 104,451 patients cared for by 100 anticoagulation clinics in the Veterans Health Administration (VA). For each site, we computed the average follow-up interval after low (≤1.5) or or high (≥4.0) INR. Our outcome was each site's average anticoagulation control, measured by percent time in therapeutic range (TTR); 59 837 patients (57%) contributed to the low INR analysis, 37 697 (36%) contributed to the high INR analysis, and all patients contributed to the dependent variable (mean site TTR). After a low INR, site mean follow-up interval ranged from 10 to 24 days. Longer follow-up intervals were associated with worse site-level control (1.04% lower for each additional day, P<0.001). After a high INR, site mean follow-up interval ranged from 6 to 18 days, with longer follow-up intervals associated with worse site-level control (1.12% lower for each additional day, P<0.001). These relationships were somewhat attenuated but still highly statistically significant when the proportion of INR values in-range was used as the dependent variable rather than TTR.
Conclusions- Prompt repeat testing after out-of-range INR values is associated with better anticoagulation control at the site level and could be an important part of a quality improvement effort for oral anticoagulation.
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Citation: Circ Cardiovasc Qual Outcomes. 2011 May 1;4(3):276-82. Epub 2011 Apr 19. Link to article on publisher's site
Circulation. Cardiovascular quality and outcomes
Rose, Adam J.; Hylek, Elaine M.; Berlowitz, Dan R.; Ash, Arlene S.; Reisman, Joel I.; and Ozonoff, Al, "Prompt Repeat Testing After Out-of-Range INR Values: A Quality Indicator for Anticoagulation Care" (2011). Quantitative Health Sciences Publications and Presentations. 978.