Adolescent diet and subsequent serum hormones, breast density, and bone mineral density in young women: results of the Dietary Intervention Study in Children follow-up study
Authors
Dorgan, Joanne F.Liu, Lea
Klifa, Catherine
Hylton, Nola
Shepherd, John A.
Stanczyk, Frank Z.
Snetselaar, Linda G.
Van Horn, Linda
Stevens, Victor J.
Robson, Alan
Kwiterovich, Peter O. Jr.
Lasser, Norman L.
Himes, John H.
Pettee Gabriel, Kelley
Kriska, Andrea
Ruder, Elizabeth H.
Fang, Carolyn Y.
Barton, Bruce A.
UMass Chan Affiliations
Department of Quantitative Health SciencesDocument Type
Journal ArticlePublication Date
2010-05-27Keywords
AdolescentAdult
*Bone Density
Breast
Breast Neoplasms
Child
Cholesterol, LDL
Diet
*Diet, Fat-Restricted
Estradiol
Female
Follow-Up Studies
Gonadal Hormones
Humans
Mammography
Progesterone
Sex Hormone-Binding Globulin
Young Adult
Bioinformatics
Biostatistics
Epidemiology
Health Services Research
Metadata
Show full item recordAbstract
BACKGROUND: Adolescent diet is hypothesized to influence breast cancer risk. We evaluated the long-term effects of an intervention to lower fat intake among adolescent girls on biomarkers that are related to breast cancer risk in adults. METHODS: A follow-up study was conducted on 230 girls who participated in the Dietary Intervention Study in Children (DISC), in which healthy, prepubertal, 8 to 10 year olds were randomly assigned to usual care or to a behavioral intervention that promoted a reduced fat diet. Participants were 25 to 29 years old at follow-up visits. All tests of statistical significance are two-sided. RESULTS: In analyses that did not take account of diet at the time of the follow-up visit, the only statistically significant treatment group difference was higher bone mineral content in intervention group participants compared with usual care group participants; their mean bone mineral contents were 2,444 and 2,377 g, respectively. After adjustment for current diet, the intervention group also had statistically significantly higher bone mineral density and luteal phase serum estradiol concentrations. Serum progesterone concentrations and breast density did not differ by treatment group in unadjusted or adjusted analyses. CONCLUSIONS: Results do not support the hypothesis that consumption of a lower fat diet during adolescence reduces breast cancer risk via effects on subsequent serum estradiol and progesterone levels, breast density, or bone mineral density. It remains unclear, however, if the results are specific to the DISC intervention or are more broadly applicable. IMPACT: Modest reductions in fat intake during adolescence are unlikely to lower later breast cancer risk via long-term effects on the biomarkers measured.Source
Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1545-56. Epub 2010 May 25. Link to article on publisher's siteDOI
10.1158/1055-9965.EPI-09-1259Permanent Link to this Item
http://hdl.handle.net/20.500.14038/47834PubMed ID
20501774Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1158/1055-9965.EPI-09-1259