Comparison of efficacy, safety, and cost of low-molecular-weight heparin with continuous-infusion unfractionated heparin for initiation of anticoagulation after mechanical prosthetic valve implantation

UMMS Affiliation

Department of Quantitative Health Sciences

Publication Date


Document Type



Anticoagulants; Case-Control Studies; Female; *Heart Valve Prosthesis Implantation; Heparin; Heparin, Low-Molecular-Weight; Hospital Costs; Humans; Infusions, Intravenous; Length of Stay; Male; Middle Aged; Safety; Warfarin


Biostatistics | Epidemiology | Health Services Research


We compared the efficacy, safety, and impact on postoperative hospital length of stay and inpatient hospital costs of low-molecular-weight heparin with that of unfractionated heparin as a "bridge" to achieving therapeutic levels of anticoagulation with warfarin in patients with newly implanted prosthetic heart valves. The patients who received low-molecular-weight heparin had a shorter length of stay and decreased postoperative costs compared with the control subjects receiving unfractionated heparin.

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Citation: Am J Cardiol. 2004 Jan 15;93(2):247-50.

Journal/Book/Conference Title

The American journal of cardiology

PubMed ID


Related Resources

Link to Article in PubMed