Do neighborhood socioeconomic deprivation and low social cohesion predict coronary calcification?: the CARDIA study
Department of Quantitative Health Sciences
Medical Subject Headings
Adolescent; Adult; Calcinosis; Catchment Area (Health); Confidence Intervals; Coronary Artery Disease; Female; Humans; *Interpersonal Relations; Male; Middle Aged; Predictive Value of Tests; Prevalence; Prospective Studies; Research Design; *Residence Characteristics; Severity of Illness Index; Socioeconomic Factors; United States; Young Adult
Bioinformatics | Biostatistics | Epidemiology | Health Services Research
Growing evidence suggests that neighborhood characteristics may influence the risk of coronary heart disease. No studies have yet explored associations of neighborhood attributes with subclinical atherosclerosis in younger adult populations. Using data on 2,974 adults (1,699 women, 1,275 men) aged 32-50 years in 2000 from the Coronary Artery Disease Risk Development in Young Adults (CARDIA) Study and 2000 US Census block-group-level data, the authors estimated multivariable-adjusted associations of neighborhood socioeconomic deprivation and perceived neighborhood cohesion with odds of coronary artery calcification (CAC) 5 years later. Among women, the quartiles of highest neighborhood deprivation and lowest cohesion were associated with higher odds of CAC after adjustment for individual-level demographic and socioeconomic factors (for deprivation, odds ratio = 2.49, 95% confidence interval: 1.22, 5.08 (P for trend = 0.03); for cohesion, odds ratio = 1.87, 95% confidence interval: 1.10, 3.16 (P for trend = 0.02)). Associations changed only slightly after adjustment for behavioral, psychosocial, and biologic factors. Among men, neither neighborhood deprivation nor cohesion was related to CAC. However, among men in deprived neighborhoods, low cohesion predicted higher CAC odds (for interaction between neighborhood deprivation and cohesion, P = 0.03). This study provides evidence on associations of neighborhood deprivation and cohesion with CAC in younger, asymptomatic adults. Neighborhood attributes may contribute to subclinical atherosclerosis.
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Citation: Am J Epidemiol. 2010 Aug 1;172(3):288-98. Epub 2010 Jul 7. Link to article on publisher's site