Title

Clinical correlations of one-carbon metabolism abnormalities

UMMS Affiliation

Department of Quantitative Health Sciences

Date

1-1-1988

Document Type

Article

Medical Subject Headings

Bipolar Disorder; Depressive Disorder; Erythrocytes; Humans; Methionine; Methionine Adenosyltransferase; Psychiatric Status Rating Scales; Psychotropic Drugs; S-Adenosylmethionine; Schizophrenia; Transferases

Disciplines

Bioinformatics | Biostatistics | Epidemiology | Health Services Research

Abstract

1. Ninety psychiatric inpatients with a DSM III diagnosis of schizophrenia, mania, or major depression were studied. 2. Upon admission/transfer to the Clinical Studies Unit, and prior to discharge, measurements of symptom severity (BPRS, Ham-D, Young's Mania Scale) and blood samples were obtained. 3. Erythrocytes from these paired (admission and discharge) blood samples were assayed for methionine adenosyltransferase (MAT) activity and phosphatidylcholine (PC) content. 4. Comparisons were made between the changes in MAT Vmax, or % PC, and changes in symptom severity. 5. For the majority of the patients (79.3% of the schizophrenics; 84.6% of the depressives; and 93.8% of the manics), clinical improvement was associated with a "normalization" of enzyme activity. The association between changes in % PC and clinical response did not achieve significant correlation.

Rights and Permissions

Citation: Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(4):491-502.

Related Resources

Link to Article in PubMed