Burden of restless legs syndrome on health-related quality of life
Authors
Kushida, CleteMartin, Marie
Nikam, Prashant
Blaisdell, Bonnie
Wallenstein, Gene
Ferini-Strambi, Luigi
Ware, John E. Jr.
UMass Chan Affiliations
Department of Quantitative Health SciencesDocument Type
Journal ArticlePublication Date
2007-02-03Keywords
Adaptation, PsychologicalAdolescent
Adult
Aged
Aged, 80 and over
Comorbidity
*Cost of Illness
Depression
Female
Health Status
Humans
Male
Mental Health
Middle Aged
Quality of Life
Restless Legs Syndrome
*Sickness Impact Profile
United States
Biostatistics
Epidemiology
Health Services Research
Metadata
Show full item recordAbstract
OBJECTIVE: To quantify the total and unique burden of Restless Legs Syndrome (RLS) on patient-reported health-related quality of life (HRQoL). METHODS: The disease burden that RLS places on HRQoL was estimated by comparing Short-Form (SF-36) scores between individuals with RLS and several patient and general populations in the US. Regression methods were applied to estimate SF-36 normative values from the general population sample and statistically adjust them to match age, gender and disease comorbidity characteristics of the RLS sample. Significance tests were then used to compare the means across samples. RESULTS: All SF-36 measures were significantly below adjusted US general population norms. Five of the eight scales (physical functioning, role physical, bodily pain, general health, vitality) were below US norms by 0.8 or more standard deviations (SD), while the remaining three (social functioning, role emotional, mental health) were 0.5 SD below norm. The burden of RLS was greater on physical than on mental/emotional HRQoL (physical and mental summary scores were 1.08 and 0.40 SD below norm, respectively), and greater than that observed for type-2 diabetes. CONCLUSION: After controlling for the impact of age, gender, and disease comorbidity, RLS was associated with unique burden on both physical and mental aspects of HRQoL.Source
Qual Life Res. 2007 May;16(4):617-24. Epub 2007 Feb 1. Link to article on publisher's siteDOI
10.1007/s11136-006-9142-8Permanent Link to this Item
http://hdl.handle.net/20.500.14038/47465PubMed ID
17268935Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1007/s11136-006-9142-8