The effects of interferon alpha-2b in combination with ribavirin on health related quality of life and work productivity
Department of Quantitative Health Sciences
Medical Subject Headings
Adult; Alanine Transaminase; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Interferon Alfa-2b; Male; Middle Aged; *Quality of Life; Recurrence; Ribavirin
Biostatistics | Epidemiology | Health Services Research
BACKGROUND/AIMS: Interferon plus ribavirin is the most effective therapy for chronic hepatitis C. The aim of this study was to evaluate the effect of chronic hepatitis C and therapy on health-related quality of life and work functioning.
METHODS: Nine hundred and twelve patients with hepatitis C infection were randomized in a controlled trial of Interferon alpha 2b 3 MU tiw for 24 or 48 weeks plus ribavirin 1000-1200 mg or placebo. Questionnaire-based assessments of health-related quality of life and work functioning were performed before, during, and after treatment. Outcome measures included the SF-36 Health Survey and additional generic and specific scales. Work functioning was assessed as missed days, shorter hours or less productivity at work.
RESULTS: Pre-treatment, patients had significant impairment in five of eight SF-36 concepts compared to matched population norms. Sustained responders had a return to normal for four of these five concepts. Quality of life did not improve in non-responders. Improvements in histology, viral load or ALT values predicted improvements in quality of life. Sustained responders also had improvements in work functioning and productivity.
CONCLUSIONS: Hepatitis C patients had impaired quality of life. After combination therapy, sustained virologic responders achieved benefits in their quality of life and work functioning.
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Citation: J Hepatol. 2001 Jan;34(1):140-7. Link to article on publisher's site
McHutchison, John G.; Ware, John E. Jr.; Bayliss, Martha S.; Pianko, Stephen; Albrecht, Janice K.; Cort, Susannah; Yang, Ilsoon; and Neary, Maureen P., "The effects of interferon alpha-2b in combination with ribavirin on health related quality of life and work productivity" (2001). Quantitative Health Sciences Publications and Presentations. 582.