Title

A questionnaire to assess the generic and disease-specific health outcomes of patients with chronic hepatitis C

UMMS Affiliation

Department of Quantitative Health Sciences

Date

3-3-1998

Document Type

Article

Medical Subject Headings

Adult; Cross-Sectional Studies; Female; *Health Status; Hepatitis C, Chronic; Humans; Male; Multivariate Analysis; *Psychometrics; *Questionnaires; Reproducibility of Results; Treatment Outcome

Disciplines

Biostatistics | Epidemiology | Health Services Research

Abstract

A 69-item questionnaire measuring generic functioning and well-being and disease-specific health outcomes was developed and tested using the pre-treatment data from patients with chronic hepatitis C (CHC) participating in two randomized trials of interferon alpha-2b (n = 157). The questionnaire included all eight scales from the SF-36 and measures of nine other generic and disease-specific health concepts. Psychometric tests confirmed the assumptions underlying the construction and scoring of all generic and disease-specific scales. Cross-sectional tests of 'known groups' validity showed that CHC patients scored worse on the generic scales than patients with other chronic conditions and worse than a healthy general population. The generic and disease-specific scale scores were lower in the presence of physical findings of CHC, as hypothesized, but only the physical functioning and bodily pain scales were linked to cirrhosis or extreme alanine aminotransferase (ALT) ratios. This instrument will be useful in studies of health outcome among patients with CHC, a condition whose health burden appears to have been underestimated in studies to date.

Rights and Permissions

Citation: Qual Life Res. 1998 Jan;7(1):39-55. Link to article on publisher's site

Related Resources

Link to Article in PubMed