Serological evidence for long-term Epstein-Barr virus reactivation in children living in a holoendemic malaria region of Kenya
Authors
Piriou, ErwanKimmel, Rhonda
Chelimo, Kiprotich
Middeldorp, Jaap M.
Sumba, Peter Odada
Ploutz-Snyder, Robert
Moormann, Ann M.
Rochford, Rosemary A.
Document Type
Journal ArticlePublication Date
2009-04-22Keywords
AdolescentAntibodies, Viral
Antigens, Viral
Child
Child, Preschool
Cross-Sectional Studies
Epstein-Barr Virus Infections
Herpesvirus 4, Human
Humans
Immunoglobulin G
Infant
Kenya
Malaria
*Virus Activation
Biostatistics
Epidemiology
Health Services Research
Immunology and Infectious Disease
Pediatrics
Metadata
Show full item recordAbstract
To study the long term the effects of chronic exposure to P. falciparum malaria on Epstein-Barr virus (EBV) reactivation in children, EBV-specific antibody levels were measured in a cross-sectional survey of two groups of Kenyan children with divergent malaria exposure, varying in age from 1 to 14 years. A total of 169 children were analyzed within three age groups (1-4 years, 5-9 years and 10-14 years). Using a Luminex assay, elevated levels of IgG to EBV lytic and latent antigens were observed in children from the holoendemic malaria area; these remained elevated for each age group studied. In comparison, children from the sporadic malaria area had lower levels of EBV-specific IgG antibodies and these levels declined across age groups. These data suggest that chronic exposure to malaria may lead to long-term EBV reactivation.Source
J Med Virol. 2009 Jun;81(6):1088-93. Link to article on publisher's siteDOI
10.1002/jmv.21485Permanent Link to this Item
http://hdl.handle.net/20.500.14038/47268PubMed ID
19382256Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1002/jmv.21485