UMMS Affiliation

Department of Quantitative Health Sciences; Department of Pediatrics

Date

2-16-2008

Document Type

Article

Medical Subject Headings

Animals; Antibodies, Protozoan; Antigens, Protozoan; Child; Child, Preschool; Cross-Sectional Studies; Endemic Diseases; Humans; Immunoglobulin G; Incidence; Infant; Kenya; Longitudinal Studies; Malaria, Falciparum; Parasitemia; Plasmodium falciparum; Protozoan Proteins; Sporozoites

Disciplines

Biostatistics | Epidemiology | Health Services Research | Immunology and Infectious Disease | Pediatrics

Abstract

BACKGROUND: IgG antibodies to pre-erythrocytic antigens are involved in prevention of infection and disease in animal models of malaria but have not been associated with protection against disease in human malaria.

METHODS: Levels of IgG antibodies to circumsporozoite protein (CSP), liver-stage antigen type 1 (LSA-1), and thrombospondin-related adhesive protein (TRAP) were measured in 86 children in a malaria-holoendemic area of Kenya. The children were then monitored for episodes of clinical malaria for 52 weeks.

RESULTS: Children with high levels of IgG antibodies to CSP, LSA-1, and TRAP had a decreased risk of clinical malaria (adjusted hazard ratio, 0.29; 95% confidence interval 0.10-0.81; P = .02), a lower incidence of clinical malaria (P=.006), protection from clinical malaria with a parasite level of > or =4000 parasites/microL (P= .03), and a higher hemoglobin level at enrollment (P= .009), compared with children with lower antibody levels. Protection against malaria morbidity was associated primarily with antibodies to CSP and LSA-1.

CONCLUSIONS: Kenyan children with high levels of IgG antibodies to the pre-erythrocytic antigens CSP, LSA-1, and TRAP have a lower risk of developing clinical malaria than children without high levels of these antibodies. The decreased risk of clinical malaria may be mediated in part by prevention of high-density parasitemia.

Rights and Permissions

© 2008 by the Infectious Diseases Society of America. Citation: J Infect Dis. 2008 Feb 15;197(4):519-26. Link to article on publisher's site

Related Resources

Link to Article in PubMed

 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.