Frequencies of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency differ in highland and nearby lowland malaria-endemic areas of Kenya
Department of Quantitative Health Sciences; Department of Pediatrics
Medical Subject Headings
Adolescent; Adult; Aged; Altitude; Child; Child, Preschool; Endemic Diseases; Glucosephosphate Dehydrogenase Deficiency; Hemoglobin, Sickle; Humans; Infant; Infant, Newborn; Kenya; Malaria, Falciparum; Middle Aged; Polymorphism, Genetic; Prevalence; Residence Characteristics; Sickle Cell Trait
Biostatistics | Epidemiology | Health Services Research | Immunology and Infectious Disease | Pediatrics
Sickle cell genotype prevalence was 26% in a malaria-holoendemic lowland area compared with 3% in a highland area of Kenya. The prevalence of glucose-6-phosphate dehydrogenase deficiency was 7% and 1% in holoendemic lowland and highland areas, respectively. Lack of protective polymorphisms may contribute to morbidity and mortality during outbreaks of malaria in the highlands.
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Citation: Trans R Soc Trop Med Hyg. 2003 Sep-Oct;97(5):513-4. Link to article on publisher's site
Moormann, Ann M.; Embury, Paula E.; Opondo, J.; Sumba, Peter Odada; Ouma, J. H.; Kazura, James W.; and John, Chandy C., "Frequencies of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency differ in highland and nearby lowland malaria-endemic areas of Kenya" (2004). Quantitative Health Sciences Publications and Presentations. 385.