Frequencies of sickle cell trait and glucose-6-phosphate dehydrogenase deficiency differ in highland and nearby lowland malaria-endemic areas of Kenya

UMMS Affiliation

Department of Quantitative Health Sciences; Department of Pediatrics

Publication Date


Document Type



Adolescent; Adult; Aged; Altitude; Child; Child, Preschool; Endemic Diseases; Glucosephosphate Dehydrogenase Deficiency; Hemoglobin, Sickle; Humans; Infant; Infant, Newborn; Kenya; Malaria, Falciparum; Middle Aged; Polymorphism, Genetic; Prevalence; Residence Characteristics; Sickle Cell Trait


Biostatistics | Epidemiology | Health Services Research | Immunology and Infectious Disease | Pediatrics


Sickle cell genotype prevalence was 26% in a malaria-holoendemic lowland area compared with 3% in a highland area of Kenya. The prevalence of glucose-6-phosphate dehydrogenase deficiency was 7% and 1% in holoendemic lowland and highland areas, respectively. Lack of protective polymorphisms may contribute to morbidity and mortality during outbreaks of malaria in the highlands.

Rights and Permissions

Citation: Trans R Soc Trop Med Hyg. 2003 Sep-Oct;97(5):513-4. Link to article on publisher's site

Journal/Book/Conference Title

Transactions of the Royal Society of Tropical Medicine and Hygiene

Related Resources

Link to Article in PubMed