UMMS Affiliation

Department of Quantitative Health Sciences; Department of Pediatrics

Publication Date

3-10-2001

Document Type

Article

Subjects

Antigens, CD14; Antigens, CD4; Female; Fetus; Fluorescent Antibody Technique, Direct; HIV Infections; Humans; Immunohistochemistry; Macrophages; Malaria; Placenta; Pregnancy; Pregnancy Complications, Parasitic; RNA, Messenger; Receptors, CCR5; Receptors, Chemokine; Transcriptional Activation

Disciplines

Biostatistics | Epidemiology | Health Services Research | Immunology and Infectious Disease

Abstract

Malaria and human immunodeficiency virus (HIV) coinfections are common in pregnant women in sub-Saharan Africa. The current study shows that placentas of malaria-infected women contain 3 times as much CC chemokine receptor 5 (CCR5) RNA as placentas of women without malaria. By immunohistochemistry, CCR5(+) maternal macrophages were seen in placentas from malaria-infected women but not in placentas from malaria-uninfected women. In addition, CCR5 also was found on fetal Hofbauer cells in placentas from both groups. Thus, malaria infections increase the potential reservoir for HIV in the placenta by increasing the number of HIV target cells.

Rights and Permissions

© 2001 by the Infectious Diseases Society of America. Citation: J Infect Dis. 2001 Mar 15;183(6):967-72. Epub 2001 Feb 9. Link to article on publisher's site

Journal/Book/Conference Title

The Journal of infectious diseases

Related Resources

Link to Article in PubMed

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