Comparison of outcomes research with clinical trials using preexisting data

UMMS Affiliation

Department of Quantitative Health Sciences



Document Type


Medical Subject Headings

Bias (Epidemiology); *Cardiology; Causality; Cohort Studies; Confounding Factors (Epidemiology); Data Collection; *Databases, Factual; Ethics, Medical; *Health Services Research; Humans; *Outcome Assessment (Health Care); *Randomized Controlled Trials as Topic; Research Design


Bioinformatics | Biostatistics | Epidemiology | Health Services Research


Outcomes research using analysis of preexisting data is a relatively new field with the potential to improve the quality and effectiveness of medical care, and may provide a useful complement to randomized studies. Motivated by the growth of this research in the cardiovascular literature, this review offers a framework to identify the core concepts of outcomes research from database analyses by comparing and contrasting it with the randomized clinical trial.

Rights and Permissions

Citation: Am J Cardiol. 1999 Oct 15;84(8):923-7, A6.

Related Resources

Link to Article in PubMed