Patterns of comorbidity in older adults with heart failure: the Cardiovascular Research Network PRESERVE study
Department of Quantitative Health Sciences; Meyers Primary Care Institute; Department of Medicine, Division of Cardiovascular Medicine; Department of Medicine, Division of Geriatric Medicine;
Medical Subject Headings
Adult; Aged; Aged, 80 and over; Comorbidity; Cross-Sectional Studies; Digestive System Diseases; Female; Follow-Up Studies; Heart Failure; History, Ancient; Humans; Male; Mental Disorders; Middle Aged; Neoplasms; Retrospective Studies; Stroke Volume; United States; Young Adult
Bioinformatics | Biostatistics | Cardiology | Cardiovascular Diseases | Epidemiology | Health Services Research
OBJECTIVES: To examine whether the total burden of comorbidity and pattern of co-occurring conditions varies in individuals with heart failure (HF) with preserved left ventricular ejection fraction (LVEF) (HF-P) or HF with reduced LVEF (HF-R). DESIGN: Cross-sectional cohort study.
SETTING: Four participating health plans within the National Heart, Lung, and Blood Institute-sponsored Cardiovascular Research Network.
PARTICIPANTS: All members aged 65 and older with HF based on hospital discharge and ambulatory visit diagnoses.
MEASUREMENTS: Participants with a LVEF of 50% or greater were classified as having HF-P. Presence of cardiac and noncardiac comorbidities was obtained from health plan administrative databases.
RESULTS: Of 23,435 individuals identified with HF and LVEF information, 53% (12,407) had confirmed HF-P (mean age 79.6; 60% female). More than three-quarters of the sample had three or more co-occurring conditions in addition to HF, and half had five or more cooccurring conditions. Participants with HF-P had a slightly higher burden of comorbidity than those with HF-R (mean 4.5 vs 4.4, P = .002). Patterns of how specific conditions co-occurred did not vary in participants with preserved or reduced systolic function.
CONCLUSION: There is a high degree of comorbidity and multiple morbidity in individuals with HF. The burden and pattern of comorbidity varies only slightly in individuals with preserved or reduced LVEF. Geriatrics Society.
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Citation: J Am Geriatr Soc. 2013 Jan;61(1):26-33. doi: 10.1111/jgs.12062. Link to article on publisher's site
Saczynski, Jane S.; Go, Alan S.; Magid, David J.; Smith, David H.; McManus, David D.; Allen, Larry; Ogarek, Jessica; Goldberg, Robert J.; and Gurwitz, Jerry H., "Patterns of comorbidity in older adults with heart failure: the Cardiovascular Research Network PRESERVE study" (2013). Quantitative Health Sciences Publications and Presentations. 1093.