Treatment outcomes of different prognostic groups of patients on cancer and leukemia group B trial 39801: induction chemotherapy followed by chemoradiotherapy compared with chemoradiotherapy alone for unresectable stage III non-small cell lung cancer
Authors
Stinchcombe, Thomas E.Hodgson, Lydia
Herndon, James E. 2nd
Kelley, Michael J.
Cicchetti, M. Giulia
Ramnath, Nithya
Niell, Harvey B.
Atkins, James N.
Akerley, Wallace
Green, Mark R.
Vokes, Everett E.
Document Type
Journal ArticlePublication Date
2009-09-01
Metadata
Show full item recordAbstract
BACKGROUND: In Cancer and Leukemia Group B 39801, we evaluated whether induction chemotherapy before concurrent chemoradiotherapy would result in improved survival and demonstrated no significant benefit from the addition of induction chemotherapy. The primary objective of this analysis was to dichotomize patients into prognostic groups using factors predictive of survival and to investigate whether induction chemotherapy was beneficial in either prognostic group. PATIENTS AND METHODS: A Cox proportional hazard model was used to assess the impact on survival of the following factors: (>or=70 versus <70 years), gender, race, stage (IIIB versus IIIA), hemoglobin (hgb) (<13 versus >or=13 g/dl), performance status (PS) (1 versus 0), weight loss (>or=5% versus <5%), treatment arm, and the interaction between weight loss and hgb. RESULTS: Factors predictive of decreased survival were weight loss >or=5%, age >or=70 years, PS of 1, and hgb <13 g/dl (p < 0.05). Patients were classified as having >or=2 poor prognostic factors (n = 165) or or=2 versus patients with or=2 factors (HR = 0.86, 95% CI, 0.63-1.17; p = 0.34) or CONCLUSIONS: There is no evidence that induction chemotherapy is beneficial in either prognostic group.Source
J Thorac Oncol. 2009 Sep;4(9):1117-25. doi: 10.1097/JTO.0b013e3181b27b33. Link to article on publisher's siteDOI
10.1097/JTO.0b013e3181b27b33Permanent Link to this Item
http://hdl.handle.net/20.500.14038/46485PubMed ID
19652624Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1097/JTO.0b013e3181b27b33