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Authors
Atagun, Murat IlhanSikoglu, Elif M.
Soykan, Caglar
Serdar Suleyman, Can
Ulusoy-Kaymak, Semra
Caykoylu, Ali
Algin, Oktay
Phillips, Mary Louise.
Ongur, Dost
Moore, Constance M.
UMass Chan Affiliations
Department of PsychiatryDocument Type
Journal ArticlePublication Date
2017-01-01Keywords
Auditory cortexBipolar disorder
GABA
Magnetic resonance spectroscopy
Schizophrenia
Mental and Social Health
Mental Disorders
Neuroscience and Neurobiology
Psychiatry
Psychiatry and Psychology
Metadata
Show full item recordAbstract
The aim of this study is to measure GABA levels of perisylvian cortices in schizophrenia and bipolar disorder patients, using proton magnetic resonance spectroscopy (1H-MRS). Patients with schizophrenia (n=25), bipolar I disorder (BD-I; n=28) and bipolar II disorder (BD-II; n=20) were compared with healthy controls (n=30). 1H-MRS data was acquired using a Siemens 3T whole body scanner to quantify right and left perisylvian structures' (including superior temporal lobes) GABA levels. Right perisylvian GABA values differed significantly between groups [chi2=9.62, df: 3, p=0.022]. GABA levels were significantly higher in the schizophrenia group compared with the healthy control group (p=0.002). Furthermore, Chlorpromazine equivalent doses of antipsychotics correlated with right hemisphere GABA levels (r2=0.68, p=0.006, n=33). GABA levels are elevated in the right hemisphere in patients with schizophrenia in comparison to bipolar disorder and healthy controls. The balance between excitatory and inhibitory controls over the cortical circuits may have direct relationship with GABAergic functions in auditory cortices. In addition, GABA levels may be altered by brain regions of interest, psychotropic medications, and clinical stage in schizophrenia and bipolar disorder.Source
Neurosci Lett. 2017 Jan 10;637:70-74. doi: 10.1016/j.neulet.2016.11.051. Epub 2016 Nov 24. Link to article on publisher's siteDOI
10.1016/j.neulet.2016.11.051Permanent Link to this Item
http://hdl.handle.net/20.500.14038/46228PubMed ID
27890741Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.neulet.2016.11.051