Anxiety and Nicotine Dependence: Emerging Role of the Habenulo-Interpeduncular Axis
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UMass Chan Affiliations
Graduate School of Biomedical SciencesTapper Lab
Brudnick Neuropsychiatric Research Institute
Department of Psychiatry
Document Type
Journal ArticlePublication Date
2017-02-01Keywords
anxietyfear
interpeduncular nucleus
medial habenula
nicotine withdrawal
Mental and Social Health
Mental Disorders
Neuroscience and Neurobiology
Psychiatry
Psychiatry and Psychology
Substance Abuse and Addiction
Metadata
Show full item recordAbstract
While innovative modern neuroscience approaches have aided in discerning brain circuitry underlying negative emotional behaviors including fear and anxiety responses, how these circuits are recruited in normal and pathological conditions remains poorly understood. Recently, genetic tools that selectively manipulate single neuronal populations have uncovered an understudied circuit, the medial habenula (mHb)-interpeduncular (IPN) axis, that modulates basal negative emotional responses. Interestingly, the mHb-IPN pathway also represents an essential circuit that signals heightened anxiety induced by nicotine withdrawal. Insights into how this circuit interconnects with regions more classically associated with anxiety, and how chronic nicotine exposure induces neuroadaptations resulting in an anxiogenic state, may thereby provide novel strategies and molecular targets for therapies that facilitate smoking cessation, as well as for anxiety relief.Source
Trends Pharmacol Sci. 2017 Feb;38(2):169-180.Link to article on publisher's site
DOI
10.1016/j.tips.2016.11.001Permanent Link to this Item
http://hdl.handle.net/20.500.14038/46225PubMed ID
27890353Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.tips.2016.11.001