Increased depressive symptoms in menopausal age women with bipolar disorder: age and gender comparison
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UMass Chan Affiliations
Department of PsychiatryDocument Type
Journal ArticlePublication Date
2009-05-01Keywords
AdultAge Factors
Bipolar Disorder
California
Comorbidity
Depression
Female
Humans
Longitudinal Studies
Male
Menopause
Middle Aged
Outpatients
Psychiatric Status Rating Scales
Sex Factors
Psychiatry
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Show full item recordAbstract
OBJECTIVE: Emerging data suggest the menopausal transition may be a time of increased risk for depression. This study examines the course of bipolar disorder focusing on depressive symptoms in menopausal transition age women, compared to similar-aged men as well as younger adult women and men. METHODS: Outpatients with bipolar disorder were assessed with the systematic treatment enhancement program for bipolar disorder (STEP-BD) affective disorders evaluation and longitudinally monitored during naturalistic treatment with the STEP-BD clinical monitoring form. Clinical status (syndromal/subsyndromal depressive symptoms, syndromal/subsyndromal elevation or mixed symptoms, and euthymia) was compared between menopausal transition age women (n=47) and pooled similar-aged men (n=30) 45-55 years old, younger women (n=48) and men (n=39) 30-40 years old. RESULTS: Subjects included 164 bipolar disorder patients (67 type I, 82 type II, and 15 not otherwise specified), 34% were rapid cycling and 58% women. Bipolar II disorder/bipolar NOS was more common in women. Monitoring averaged 30+/-22 months, with an average of 0.9+/-0.5 clinic visits/month. Menopausal age women had a significantly greater proportion of visits with depressive symptoms (p<0.05), significantly fewer euthymic visits (p<0.05) and no difference in proportion of visits with elevated/mixed symptoms compared to pooled comparison group. CONCLUSIONS: Menopausal transition age women with bipolar disorder experience a greater proportion of clinic visits with depressive symptoms compared to similarly aged men, and younger women and men with bipolar disorder. Further systematic assessment on the influence of the menopausal transition and reproductive hormones upon mood is needed to better inform clinical practice in treating women with bipolar disorder.Source
J Psychiatr Res. 2009 May;43(8):798-802. Epub 2009 Jan 19. Link to article on publisher's siteDOI
10.1016/j.jpsychires.2008.11.003Permanent Link to this Item
http://hdl.handle.net/20.500.14038/45991PubMed ID
19155021Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.jpsychires.2008.11.003