The molecular pathology of schizophrenia--focus on histone and DNA modifications
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Authors
Akbarian, SchahramUMass Chan Affiliations
Department of PsychiatryDocument Type
Journal ArticlePublication Date
2010-09-30Keywords
AnimalsCerebral Cortex
*DNA
DNA Methylation
Epigenesis, Genetic
Histones
Humans
*Pathology, Molecular
Schizophrenia
Psychiatry
Metadata
Show full item recordAbstract
Dysfunction of cerebral cortex and other brain regions in schizophrenia is often accompanied by dysregulated expression of numerous genes. However, the underlying genetic risk architecture remains unclear for a large majority of cases. Therefore, the study of epigenetic regulators of gene expression, including covalent modifications of DNA and nucleosome core histones, offers an attractive alternative to further explore the molecular pathology of schizophrenia beyond the level of RNA quantification. Several studies reported alterations in DNA cytosine methylation and histone methylation at specific genes and promoters in postmortem brain of subjects with schizophrenia, often in conjunction with changes in levels of the corresponding RNAs. While evidence for such "epigenetic dysregulation" is increasing, many of the reported alterations await independent replication. Interestingly, studies across the lifespan indicate that DNA and histone methylation markings are developmentally regulated in human cerebral cortex, suggesting that at least some of the epigenetic changes in the brain of adult subjects with schizophrenia reflect disordered neurodevelopment.Source
Brain Res Bull. 2010 Sep 30;83(3-4):103-7. Epub 2009 Sep 1. Link to article on publisher's siteDOI
10.1016/j.brainresbull.2009.08.018Permanent Link to this Item
http://hdl.handle.net/20.500.14038/45985PubMed ID
19729053Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.brainresbull.2009.08.018