UMass Chan Affiliations
Department of PsychiatryDocument Type
Journal ArticlePublication Date
2008-08-02Keywords
AdolescentAge of Onset
Antipsychotic Agents
Child
Diagnosis, Differential
Humans
Psychiatric Status Rating Scales
Schizophrenia
Schizophrenic Psychology
Psychiatry
Metadata
Show full item recordAbstract
BACKGROUND: Childhood-onset schizophrenia is a serious, chronic and disabling illness that can significantly affect the quality of life of the affected individuals and their families. The affected children commonly show significant premorbid developmental impairment and social abnormalities that may provide an early clinical clue to pursue treatment. Until recent times, treatment approaches for childhood schizophrenia were derived from the adult population. However, given the unique developmental challenges in the pediatric population, this extrapolation may not hold true. OBJECTIVE: This review encompasses and elaborates on the efficacy, safety and tolerability data available at present for both typical and atypical antipsychotics for treatment of childhood schizophrenia. METHOD: A literature search was conducted on PUBMED with special emphasis on double-blind placebo-controlled studies in childhood schizophrenia. Data from similar studies presented in recent meetings were also added to the review. CONCLUSIONS: Recent research in pediatric psychopharmacology has led to the Food and Drug Administration's approval of two atypical antipsychotics for the treatment of schizophrenia. Although data in this age group are still sparse, research in this unique population has grown over the years.Source
Expert Opin Pharmacother. 2008 Aug;9(12):2053-68. Link to article on publisher's siteDOI
10.1517/14656566.9.12.2053Permanent Link to this Item
http://hdl.handle.net/20.500.14038/45955PubMed ID
18671461Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1517/14656566.9.12.2053