Magnetic Resonance Imaging Studies in Early Onset Bipolar Disorder: An Updated Review
Department of Psychiatry
Medical Subject Headings
Bipolar Disorder; Magnetic Resonance Imaging; Adolescent
Over the past 5–10 years, advances in neuroimaging methods and study designs have begun to appear in the literature of early-onset bipolar disorder (onset before 18 years of age). This article contains an updated review of the literature regarding neuroimaging in youths with bipolar disorder (BPD), highlighting important new study designs and techniques. Overall, structural, functional (fMRI) and magnetic resonance spectroscopy (MRS) report consistent abnormalities in regions of the frontal lobe and limbic structures. Functional MRI and MRS studies also frequently report striatal and thalamic abnormalities in early-onset BPD. Future neuroimaging studies in youths with BPD should include longitudinal studies incorporating multimodal neuroimaging techniques.
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Citation: Janine Terry, Melissa Lopez-Larson, Jean A. Frazier. Magnetic Resonance Imaging Studies in Early Onset Bipolar Disorder: An Updated Review. Child and Adolescent Psychiatric Clinics of North America - April 2009 (Vol. 18, Issue 2, Pages 421-439, DOI: 10.1016/j.chc.2008.12.004).