Donepezil in the treatment of ADHD-like symptoms in youths with pervasive developmental disorder: a case series

UMMS Affiliation

Department of Psychiatry



Document Type


Medical Subject Headings

Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child Development Disorders, Pervasive; Cholinesterase Inhibitors; Communication; Drug Administration Schedule; Female; Humans; Indans; Male; Piperidines; Social Behavior




BACKGROUND: Recent studies reported ADHD-like symptoms and cognitive deficits in pervasive developmental disorder (PDD). Because work in dementia documents improvement in executive function deficits with the acetylcholinesterase inhibitor donepezil, the authors reason that similar benefits could be obtained in PDD.

METHOD: The authors describe eight cases of PDD youth ages 10 to 17 treated with donepezil targeting ADHD-like symptoms associated with PDD.

RESULTS: Most participants improve ADHD-like symptomatology. In addition, improvement in communication and socialization is noted.

CONCLUSION: Donepezil may have a role in treating ADHD-like symptoms in children with PDD.

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Citation: J Atten Disord. 2006 Feb;9(3):543-9. Link to article on publisher's site

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