Risperidone treatment for juvenile bipolar disorder: a retrospective chart review
Department of Psychiatry
Medical Subject Headings
Adolescent; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Child; Child Development Disorders, Pervasive; Child, Preschool; Female; Humans; Male; Retrospective Studies; Risperidone; Severity of Illness Index; Treatment Outcome
OBJECTIVE: To investigate the effectiveness and tolerability of the atypical neuroleptic risperidone in the treatment of juvenile mania.
METHOD: This is a retrospective chart review of outpatients with the diagnosis of bipolar disorder (DSM-IV) treated with risperidone at a university center. Response to treatment was evaluated using the Clinical Global Impression Scale (CGI) with separate assessments of mania, psychosis, aggression, and attention-deficit/hyperactivity disorder (ADHD).
RESULTS: Twenty-eight youths (mean +/- SD age, 10.4 +/- 3.8 years) with bipolar disorder (25 mixed and 3 hypomanic) who had been treated with risperidone were identified. These children received a mean dose of 1.7 +/- 1.3 mg over an average period of 6.1 +/- 8.5 months. Using a CGI Improvement score of < or = 2 (very much/much improved) to define robust improvement, 82% showed improvement in both their manic and aggressive symptoms, 69% in psychotic symptoms, but only 8% in ADHD symptoms.
CONCLUSIONS: Although limited by its retrospective nature, this study suggests that risperidone may be effective in the treatment of manic young people and indicates the need for controlled clinical trials of risperidone and other atypical neuroleptics in juvenile mania.
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Citation: J Am Acad Child Adolesc Psychiatry. 1999 Aug;38(8):960-5. Link to article on publisher's site
Frazier, Jean A.; Meyer, Michelle C.; Biederman, Joseph; Wozniak, Janet; Wilens, Timothy E.; Spencer, Thomas J.; Kim, Grace S.; and Shapiro, Stephanie, "Risperidone treatment for juvenile bipolar disorder: a retrospective chart review" (1999). Psychiatry Publications and Presentations. 380.