An open trial of clozapine in 11 adolescents with childhood-onset schizophrenia

UMMS Affiliation

Department of Psychiatry



Document Type


Medical Subject Headings

Adolescent; Child; Clozapine; Double-Blind Method; Female; Haloperidol; Humans; Male; Psychiatric Status Rating Scales; Schizophrenia, Childhood




OBJECTIVE: To review the response of 11 adolescents with childhood-onset schizophrenia to a 6-week open clozapine trial.

METHOD: Eleven children meeting DSM-III-R criteria for schizophrenia had a 6-week open trial of clozapine (mean sixth week daily dose 370 mg). Behavioral ratings included the Brief Psychiatric Rating Scale and Children's Global Assessment Scale.

RESULTS: More than half showed marked improvement in Brief Psychiatric Rating Scale ratings by 6 weeks of clozapine therapy compared to admission drug rating and compared to a systematic 6-week trial of haloperidol.

CONCLUSIONS: This open trial indicates that clozapine may be a promising treatment for children and adolescents with schizophrenia who do not respond well to typical neuroleptics. A double-blind placebo-controlled study is ongoing.

Rights and Permissions

Citation: J Am Acad Child Adolesc Psychiatry. 1994 Jun;33(5):658-63. Link to article on publisher's site

Related Resources

Link to Article in PubMed

PubMed ID