Toward a biochemical classification of depressive disorders IX. DST results and platelet MAO activity
Department of Psychiatry
Medical Subject Headings
Adult; Age Factors; Aged; Blood Platelets; Depressive Disorder; Dexamethasone; Female; Humans; Hydrocortisone; Male; Middle Aged; Monoamine Oxidase
Post-dexamethasone cortisol and platelet monoamine oxidase (MAO) activity levels were examined in 50 depressed patients. The incidence of non-suppression was significantly greater in patients with high platelet MAO activity than in those with low activity. Similar results were obtained when males and females were analysed separately. The mean 4 p.m. post-dexamethasone cortisol level was significantly higher in those patients who had high MAO activity than in their low MAO counterparts. Moreover, a statistically significant positive correlation was observed between platelet MAO activity and 4 p.m. post-dexamethasone cortisol levels.
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Citation: Br J Psychiatry. 1985 Jun;146:633-7.
Schatzberg, Alan F.; Rothschild, Anthony J.; Gerson, B.; Lerbinger, Jan E.; and Schildkraut, Joseph J., "Toward a biochemical classification of depressive disorders IX. DST results and platelet MAO activity" (1985). Psychiatry Publications and Presentations. 20.