Title

Risperidone decreases craving and relapses in individuals with schizophrenia and cocaine dependence

UMMS Affiliation

Department of Veterans Affairs

Date

10-3-2002

Document Type

Article

Medical Subject Headings

Adult; Antipsychotic Agents; Cocaine-Related Disorders; Comorbidity; Female; Humans; Male; Middle Aged; Motivation; Pilot Projects; Psychiatric Status Rating Scales; Recurrence; Risperidone; Schizophrenia; *Schizophrenic Psychology; Substance Withdrawal Syndrome

Disciplines

Psychiatry

Abstract

OBJECTIVE: To examine the efficacy of atypical neuroleptics for decreasing craving and drug relapses during protracted withdrawal in individuals dually diagnosed with schizophrenia and cocaine dependence.

METHOD: We conducted a 6-week, open-label pilot study comparing risperidone with typical neuroleptics in a sample of withdrawn cocaine-dependent schizophrenia patients.

RESULTS: Preliminary results suggest that individuals treated with risperidone had significantly less cue-elicited craving and substance abuse relapses at study completion. Further, they showed a trend toward a greater reduction in negative and global symptoms of schizophrenia.

CONCLUSION: Atypical neuroleptics may help reduce craving and relapses in this population. Future research should include more rigorous double-blind placebo-controlled studies with this class of medications.

Rights and Permissions

Citation: Can J Psychiatry. 2002 Sep;47(7):671-5.

Related Resources

Link to Article in PubMed

PubMed ID

12355680