Risperidone decreases craving and relapses in individuals with schizophrenia and cocaine dependence
Department of Veterans Affairs
Medical Subject Headings
Adult; Antipsychotic Agents; Cocaine-Related Disorders; Comorbidity; Female; Humans; Male; Middle Aged; Motivation; Pilot Projects; Psychiatric Status Rating Scales; Recurrence; Risperidone; Schizophrenia; *Schizophrenic Psychology; Substance Withdrawal Syndrome
OBJECTIVE: To examine the efficacy of atypical neuroleptics for decreasing craving and drug relapses during protracted withdrawal in individuals dually diagnosed with schizophrenia and cocaine dependence.
METHOD: We conducted a 6-week, open-label pilot study comparing risperidone with typical neuroleptics in a sample of withdrawn cocaine-dependent schizophrenia patients.
RESULTS: Preliminary results suggest that individuals treated with risperidone had significantly less cue-elicited craving and substance abuse relapses at study completion. Further, they showed a trend toward a greater reduction in negative and global symptoms of schizophrenia.
CONCLUSION: Atypical neuroleptics may help reduce craving and relapses in this population. Future research should include more rigorous double-blind placebo-controlled studies with this class of medications.
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Citation: Can J Psychiatry. 2002 Sep;47(7):671-5.
Smelson, David A.; Losonczy, Miklos F.; Davis, Craig W.; Kaune, Maureen; Williams, John; and Ziedonis, Douglas M., "Risperidone decreases craving and relapses in individuals with schizophrenia and cocaine dependence" (2002). Psychiatry Publications and Presentations. 183.