Title

A pilot trial of gepirone vs. placebo in the treatment of cocaine dependency

UMMS Affiliation

Department of Psychiatry

Date

1-1-1992

Document Type

Article

Medical Subject Headings

Adult; Antidepressive Agents; *Cocaine; Double-Blind Method; Female; Humans; Male; Pilot Projects; Placebos; Pyrimidines; Substance-Related Disorders

Disciplines

Psychiatry

Abstract

An interim analysis of 41 evaluable patients compared gepirone to placebo treatment in a randomized, double-blind, 12-week study of cocaine dependence without opiate abuse. The response to gepirone at a mean dose of 16.25 mg/day did not differ from placebo by measures of time in study, positive urine cocaine screens (greater than 6 weeks), Clinical Global Impressions (CGI) Global Improvements Scale, Cocaine Craving Scale (CCS), Quantitative Cocaine Inventory (QCI), Addiction Severity Index (ASI), Global Assessment Scale (GAS), Hamilton Rating Scale for Depression (HAM-D), and Hamilton Anxiety Scale (HAM-A). Both treatment groups showed similar modest, average improvements during the study in all treatment measures. Adverse events were not treatment limiting. The following demographic and study measures suggested favorable trends for study outcomes: older age, divorced status, higher pre-treatment cocaine use, lower CCS scores, and lower self-reports of cocaine use according to QCI.

Rights and Permissions

Citation: Psychopharmacol Bull. 1992;28(1):21-6.

Related Resources

Link to Article in PubMed

PubMed ID

1609038

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